Status:
NOT_YET_RECRUITING
Pathogenesis of Periodontal Disease in Individuals With Psoriasis
Lead Sponsor:
Recep Tayyip Erdogan University Training and Research Hospital
Conditions:
Psoriasis
Eligibility:
All Genders
18-65 years
Brief Summary
The aim of this study is to evaluate the levels of Th17 cell-associated cytokines (IL-17, IL-21, IL-23) and the salivary stress biomarkers cortisol, dehydroepiandrosterone, and Chromogranin A in the p...
Detailed Description
Psoriasis and periodontitis are chronic inflammatory diseases, and Th17 cells and their secreted cytokines, such as IL-17, IL-21, and IL-23, have been shown to play a significant role in the pathogene...
Eligibility Criteria
Inclusion
- Being between the ages of 18 and 65
- Being diagnosed with psoriasis by a dermatologist
- Having at least 20 teeth
- Not having received periodontal treatment in the last 6 months
- Not having taken antibiotics, steroids, and/or nonsteroidal anti-inflammatory drugs in the last 3 weeks
- Not having any autoimmune disease, osteoporosis, or cancer
- Not using immunosuppressive drugs, oral contraceptives, or bisphosphonates
- Not being pregnant
- Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS)
- Not using chronic medications that affect periodontal tissues (cyclosporine A, phenytoin)
- Not having taken antioxidant supplements in the last 6 months
Exclusion
- \<20 teeth
- Any significant oral infection (i.e., herpes or candidiasis)
- Oral injuries or bleeding unrelated to periodontitis
- Periodontal therapy and antibiotic therapy within the past 3 months
- Salivary gland dysfunction
- Acute illness (fever, sore throat)
- Systemic illness, mental illness, immunosuppressive drugs or immunodeficiency
- Pregnancy or breastfeeding
- Use of antidepressants
Key Trial Info
Start Date :
September 15 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 6 2026
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT07158125
Start Date
September 15 2025
End Date
April 6 2026
Last Update
September 5 2025
Active Locations (1)
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1
Department of Periodontology of the Faculty of Dentistry of Recep Tayyip Erdogan University
Rize, Rize Province, Turkey (Türkiye), 53200