Status:
RECRUITING
Efficacy of Methylprednisolone for Pain Control After ACL Repair
Lead Sponsor:
St. Louis University
Conditions:
ACL Surgery
Pain Management
Eligibility:
All Genders
13-50 years
Phase:
PHASE4
Brief Summary
Opioids are commonly used after orthopedic surgery for pain control but have been shown to increase complications, surgeries, readmissions, and risk for opioid use disorder. The purpose of this study ...
Detailed Description
The study is to include consecutive patients who undergo ACL repair by fellowship trained surgeons at a single institution with minimum 12 week follow up. All patients between the ages of 13-50 who ar...
Eligibility Criteria
Inclusion
- Patient undergoing ACL repair or ACL reconstruction with tendon autograft
- Age 13-50 years old
- Able to provide informed consent or parent/legal guardian is able for minors
Exclusion
- Concurrent and significant injury to other bones or organs (Injury Severity Score of 4 or greater)
- Revision ACL reconstruction
- Concomitant additional ligament reconstruction or high tibial osteotomy
- A history of alcohol abuse, substance abuse or chronic opioid use (filled opioid medication ×2 within 6 months of the surgery)
- A history of renal failure (\<60 mL/min/1.73 m2), liver dysfunction (child class, \>B), severe heart disease (NYHA Class 4), diabetes, neurological or psychiatric diseases that may affect pain perception, and pre-existing immune suppression.
- A history or active peptic ulcer disease, gastrointestinal bleeding, or current use of anticoagulation.
- Patients currently taking oral or injectable glucocorticoids and those who have taken either within 1 month of the procedure.
- Patients who are currently pregnant.
- Patients who are unable to undergo the multimodal pain standardized protocol including those with comorbidities or medical allergies precluding the use of corticosteroids, gabapentin, hydrocodone, acetaminophen, ketorolac, and/or meloxicam.
Key Trial Info
Start Date :
October 21 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2031
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT07158476
Start Date
October 21 2025
End Date
September 1 2031
Last Update
October 24 2025
Active Locations (1)
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1
Saint Louis University
St Louis, Missouri, United States, 63110