Status:
NOT_YET_RECRUITING
Levocarnitine for Reducing ESA Requirements in Hemodialysis Patients With Renal Anemia
Lead Sponsor:
Shaikh Zayed Hospital, Lahore
Conditions:
Anemia
Kidney Failure
Eligibility:
All Genders
20-60 years
Phase:
PHASE4
Brief Summary
Renal anemia is common in people receiving long-term hemodialysis and is usually treated with erythropoiesis-stimulating agents (ESAs). Some patients respond poorly and require high ESA doses, which i...
Detailed Description
Background and Rationale. Carnitine supports erythrocyte membrane stability and energy metabolism. In maintenance hemodialysis, endogenous carnitine synthesis is reduced and dialytic losses occur, pot...
Eligibility Criteria
Inclusion
- Both male and female patients
- Patients aged 20-60 years.
- Patients undergoing maintenance hemodialysis three times a week for at least six months
- Patients having renal anemia
Exclusion
- Patients currently using any carnitine preparation as a supplement (to avoid confounding effects from additional carnitine intake).
- Patients on immunosuppressive drugs, steroids, or antibiotics (to avoid the influence of these medications on anemia and carnitine metabolism).
- Patients who have previously received levocarnitine in either oral or injected form (to eliminate any prior influence of levocarnitine on study outcomes).
- Patients with a history of blood transfusion within the past 6 months (to exclude the immediate impact of transfusions on hemoglobin levels and anemia management).
- Patients with acute inflammation (to prevent interference with study parameters as inflammation can affect anemia status).
- Patients with communication difficulties due to dementia or other factors (to ensure accurate symptom reporting and study adherence).
Key Trial Info
Start Date :
September 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 15 2026
Estimated Enrollment :
94 Patients enrolled
Trial Details
Trial ID
NCT07160452
Start Date
September 15 2025
End Date
March 15 2026
Last Update
September 12 2025
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