Status:
NOT_YET_RECRUITING
Evaluation of Nucleotide-Binding Oligomerization Domain-Containing Protein (NOD) 1 and NOD 2
Lead Sponsor:
Medipol University
Conditions:
Periodontal Diseases Inflammation
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The host immune response to microorganisms is primarily recognized by pattern recognition receptors (PRRs), including toll-like receptors and nucleotide-binding oligomeric domain (NOD) receptors (NLRs...
Detailed Description
Healthy participants (n:25), gingivitis (n:25) patients and stage III, grade B periodontitis (n:25) patients enrolled for this study. Clinical periodontal parameters and salivary flow rate were noted....
Eligibility Criteria
Inclusion
- systemically healthy
- clinical diagnosis of periodontal health
- clinical diagnosis of periodontitis
- clinical diagnosis of gingivitis
Exclusion
- • history of regular use of systemic antibiotics anti-inflammatory, or antioxidant drugs (previous 3 months)
- nonsurgical periodontal treatment (previous 6 months)
- surgical periodontal treatment (previous 12 months)
- presence of\<10 teeth
- current medications affecting gingival health (calcium channel blockers, phenytoin, cyclosporine, and hormone replacement therapy)
- diabetes
- diagnosis of rheumatoid arthritis
- pregnancy
- lactating
- smoking
- excessive alcohol consumption.
Key Trial Info
Start Date :
September 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 20 2026
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT07160894
Start Date
September 15 2025
End Date
July 20 2026
Last Update
September 8 2025
Active Locations (1)
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1
Istanbul Medipol University, School of Dentistry
Istanbul, Fatih, Turkey (Türkiye)