Status:
COMPLETED
A Trial of Triamcinolone With a GnRH Analog for Castration Resistant Prostate Cancer
Lead Sponsor:
Barts & The London NHS Trust
Conditions:
Castration Resistant Prostate Cancer
Eligibility:
MALE
18+ years
Phase:
PHASE2
Brief Summary
When metastatic prostate cancer becomes unresponsive to hormone therapy, it is known as castration resistant prostate cancer, treatment options are limited and response to this treatment can be short....
Detailed Description
Castration resistant prostate cancer (CRPC) is a cancer which has become resistant to hormone therapy. Triamcinolone is a steroid drug, and it is hoped that when administered intra-muscularly with a g...
Eligibility Criteria
Inclusion
- Histologically confirmed adenocarcinoma of the prostate
- Progressive disease despite castration with an elevated PSA \>5ng/ml (testosterone \<1.5nmol/l or failure of GnRH analogue with peripheral anti-androgen if non-castrate level on GnRH alone)
- ECOG performance status (PS) 0-3 and considered by responsible consultant suitable to undergo treatment
- Males aged greater or equal than 18
- Patients who are able to understand their participation in the study and give written informed consent
Exclusion
- Contraindication to intramuscular injections
- Unable to titrate medication for type 2 diabetes if deterioration in control on triamcinolone
- Absolute contraindication to corticosteroids
- Previous use of corticosteroids in prostate cancer
- Previous chemotherapy for prostate cancer
- Current participation in any other investigational drug study
- History of a malignancy within 5 years except those treated with curative intent for skin cancer (other than melanoma)
Key Trial Info
Start Date :
October 19 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 24 2020
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT07161778
Start Date
October 19 2011
End Date
September 24 2020
Last Update
September 9 2025
Active Locations (3)
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1
Royal Sussex County Hospital
Brighton, United Kingdom
2
Raigmore Hospital
Inverness, United Kingdom
3
St Bartholomew's Hospital
London, United Kingdom