Status:
RECRUITING
Combined Gamma Knife/Linac Radiosurgery for Large Brain Tumors / Metastases
Lead Sponsor:
Sunnybrook Health Sciences Centre
Conditions:
Brain (Nervous System) Cancers
Brain Metastasases
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
When cancer spreads to the brain, doctors often use a precise type of radiation therapy called stereotactic radiosurgery (SRS) to treat these tumors. This treatment can effectively control brain tumor...
Eligibility Criteria
Inclusion
- Presence of up to two large intracranial lesions
- Up to 10 (previously untreated, or progressing after previous treatment) brain metastases at the time of enrollment on the diagnostic MRI (which includes the ILLs) to be treated with SRS/HSRS
- Age =\> 18 years
- Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
- Expected survival \>3 months
- Patients that are deemed suitable for both GK and Linac based treatment
- Patients that are able to hold systemic cancer chemotherapy/immunotherapy at least 2 days prior and following an SRS fraction
Exclusion
- Prior SRS to the ILLs
- Prior WBRT, or plan for concurrent WBRT with the protocol treatment
- Presence or history of any leptomeningeal/pachymeningeal disease
- Metastatic disease within the ventricles of the brain or corpus callosum
- Small cell, hematopoietic or germ cell primaries
- Patient with absolutely contraindications for MRI
- Severe symptoms that preclude MRI or treatment using standard procedures for Linac or GK
- Pregnant or lactating patient
- Inability or unwillingness to undergo informed consent or post-treatment follow-up
Key Trial Info
Start Date :
July 14 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2030
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT07162246
Start Date
July 14 2025
End Date
June 1 2030
Last Update
September 9 2025
Active Locations (1)
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1
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N3M5