Status:
COMPLETED
Propofol Dose-Finding for Colonoscope Insertion in Geriatric Patients
Lead Sponsor:
Kocaeli City Hospital
Conditions:
Effect of Drug
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
The aim of this prospective dose-finding study is to determine the ED50 of propofol required for successful colonoscope insertion in geriatric patients. The study is designed using Dixon's up-and-down...
Detailed Description
The procedure is performed by an experienced endoscopist. If, during passage of the colonoscope through the rectosigmoid junction, the patient moves, experiences pain, vocalizes, or if the MOAA/S scor...
Eligibility Criteria
Inclusion
- Patients who provided informed consent to participate
- Patients scheduled for colonoscopy
- ASA physical status I-III
- Male and female patients aged ≥65 years
Exclusion
- Patients who did not provide consent
- Known allergy to propofol
- Body weight \<40 kg
- Body mass index (BMI) \>30 kg/m²
- Presence of acute or chronic pain
- Chronic alcohol consumption
- Use of antipsychotic, antidepressant, or hypnotic medications
- Patients with obstructive sleep apnea syndrome (STOP-Bang score ≥3)
- Patients with known anorectal diseases such as hemorrhoids, anal fissure, or anal fistula
- History of oncological disease
- Uncontrolled hypertension (blood pressure \>180/110 mmHg)
- Severe hepatic or renal dysfunction
- Acute respiratory tract infection or other chronic respiratory disorders
- Patients with a history of colorectal surgery
Key Trial Info
Start Date :
September 8 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 8 2025
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT07162805
Start Date
September 8 2025
End Date
October 8 2025
Last Update
November 17 2025
Active Locations (1)
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1
University of Health Sciences Kocaeli City Hospital
Kocaeli, Izmit, Turkey (Türkiye), 41100