Status:
ENROLLING_BY_INVITATION
Prolactin, Inflammation, and Parkinson's Severity
Lead Sponsor:
Çanakkale Onsekiz Mart University
Conditions:
Idiopathic Parkinson Disease
Prolactin
Eligibility:
All Genders
18+ years
Brief Summary
This cross-sectional observational study aims to evaluate the relationship between serum prolactin levels, peripheral inflammatory markers (NLR, PLR, SII, CRP), and disease severity in patients with P...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Diagnosis of idiopathic Parkinson's disease confirmed by a neurologist
- Both male and postmenopausal female patients
- Patients able to provide informed consent
- Clinically stable enough to undergo blood and saliva sampling, as well as neurological assessment
Exclusion
- Premenopausal female patients
- Patients with secondary or atypical parkinsonism (e.g., drug-induced, vascular, atypical parkinsonian syndromes)
- Known endocrine disorders affecting prolactin levels (e.g., prolactinoma, pituitary adenoma, hypothyroidism)
- Use of medications known to alter prolactin secretion (e.g., antipsychotics, dopamine antagonists, estrogen therapy)
- History of other neurodegenerative diseases (e.g., Alzheimer's, Huntington's)
- Presence of active infection, chronic inflammatory disease, or malignancy
- Severe renal, hepatic, or cardiac failure
- Inability to provide informed consent
Key Trial Info
Start Date :
August 14 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT07163156
Start Date
August 14 2025
End Date
June 1 2026
Last Update
September 9 2025
Active Locations (1)
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1
Çanakkale Onsekiz Mart University
Çanakkale, Merkez, Turkey (Türkiye), 17020