Status:
RECRUITING
Postural Mobilization Compared to Noradrenaline Only in Off-Pump CABG Surgery
Lead Sponsor:
Infirmerie Protestante de Lyon
Conditions:
Coronary Artery Disease With Need for Bypass Surgery
Coronary Artery Disease(CAD)
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This interventional prospective randomized study is designed to compare hemodynamic management using postural mobilization (+/- noradrenaline) versus noradrenaline only in patients undergoing open-hea...
Detailed Description
OPTICAB is a single-site study in France that aims to compare two hemodynamic management techniques during off-pump coronary artery bypass graft (CABG) surgery: postural mobilization (+/- noradrenalin...
Eligibility Criteria
Inclusion
- Adult patient
- patient requiring isolated coronary bypass surgery
- Elective procedure or medical emergency
- First cardiac surgery
- Patient with an EF ≥30%
- Mandatory affiliation to a social security system
- Signed informed consent form
- Suspension of renin-angiotensin system inhibitors and angiontensn-neprilysin receptor blockers and sartans the day before surgical procedure
Exclusion
- Contraindication to an inotropic substance (only NA will be used)
- Contraindication to passive leg raising
- Patient in a life-threatening emergency
- History of cardiac surgery
- Bilateral iliac or common femoral artery occlusion
- EF \< 30%
- Pregnancy and breastfeeding
- Renal failure (GFR \< 40 ml/min/1.73 m²)
- Patient with bilateral thigh amputation
- Class III obesity BMI \> 40 kg/m²
Key Trial Info
Start Date :
October 6 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2027
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT07163858
Start Date
October 6 2025
End Date
August 1 2027
Last Update
December 3 2025
Active Locations (1)
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1
Infirmerie Protestante de Lyon
Caluire-et-Cuire, Auvergne-Rhône-Alpes, France, 69300