Status:
RECRUITING
Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactams
Lead Sponsor:
Mayo Clinic
Conditions:
Community-acquired Pneumonia
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to compare effectiveness and safety of Azithromycin versus Doxycycline in adult patients hospitalized with community acquired pneumonia (CAP) treated with Beta-lactams.
Eligibility Criteria
Inclusion
- • All adult patients (\>18 years old) admitted with CAP and receiving a beta-lactam antibiotic plus a form of atypical coverage (azithromycin or doxycycline) in the ED within 12 hours of admission.
Exclusion
- High clinical suspicion for Legionella pneumonia
- Allergy or contraindication to the use of either azithromycin or doxycycline (usual clinical practice)
- Antibiotics not for CAP
- Pregnant women (based on clinical assessment as part of standard of care)
- Severe CAP as defined by the ATS/IDSA criteria
- Corrected QT prolongation (\> 440 ms in men and \> 460 ms in women)
- Receiving a different antibiotic (e.g quinolones)
- Admission \> 24 hours
- Known to be a prisoner
Key Trial Info
Start Date :
September 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2031
Estimated Enrollment :
1120 Patients enrolled
Trial Details
Trial ID
NCT07164131
Start Date
September 15 2025
End Date
September 1 2031
Last Update
October 8 2025
Active Locations (5)
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1
Mayo Clinic in Arizona
Scottsdale, Arizona, United States, 85259
2
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224
3
Mayo Clinic Health System-Mankato
Mankato, Minnesota, United States, 56001
4
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905