Status:
NOT_YET_RECRUITING
The Eswatini Study on Neurocognitive Performance in Adolescents Living With HIV
Lead Sponsor:
Eswatini Nazarene Health Institutions
Collaborating Sponsors:
Baylor Foundation Eswatini
Conditions:
HIV (Human Immunodeficiency Virus)
Eligibility:
All Genders
13-19 years
Brief Summary
This study explores the link between inflammatory biomarkers and neurocognitive performance in adolescents living with HIV (ALHIV) in Eswatini. Persistent HIV infection during adolescence has been ass...
Detailed Description
Adolescents living with HIV (ALHIV) in sub-Saharan Africa face a complex health burden that goes beyond virological control. In Eswatini, where HIV prevalence ranks among the highest globally, the com...
Eligibility Criteria
Inclusion
- Cases
- Adolescents aged 13-19 years
- HIV-positive
- Undergoing antiretroviral therapy at Baylor Clinic
- Providing consent or assent to participate
- Controls
- Adolescents aged 13-19 years
- HIV-negative
- Providing consent or assent to participate
Exclusion
- Exclusion Criteria
- Recent (within 2 months) acute conditions: influenza, COVID-19, TB, acute gastroenteritis (as these conditions elevate CRP levels)
- Chronic conditions: diabetes, hypertension, asthma
- Neurological disorders: epilepsy, cerebrovascular accident, neurodegenerative diseases
- History of significant cranial trauma or perinatal complications
- All the aforementioned conditions will be identified through self-reported data and medical records.
Key Trial Info
Start Date :
November 30 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 31 2026
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT07165639
Start Date
November 30 2025
End Date
May 31 2026
Last Update
September 15 2025
Active Locations (1)
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1
Eswatini Nazarene Health Institution, Baylor College of Medicine Children's Foundation-Eswatini (Centers of Excellence in Mbabane and satellite clinic in Manzini in Raleigh Fitkin Memorial Hospital)
Manzini, Eswatini, M200