Status:
NOT_YET_RECRUITING
Mitigating Neural Hypoexcitability and Weakness During Disuse in Women
Lead Sponsor:
Kansas State University
Collaborating Sponsors:
National Institute of General Medical Sciences (NIGMS)
Conditions:
Muscle Weakness
Eligibility:
FEMALE
40-65 years
Phase:
NA
Brief Summary
Clinical trial The goal of this clinical trial is to learn how muscle weakness and atrophy develop during short periods of arm immobilization and whether a type of exercise called cross-education can ...
Detailed Description
This clinical trial employs a two-phase, parallel-group randomized controlled design targeting midlife women (ages 40-65), stratified by menopausal status. Participants will be randomized to either a ...
Eligibility Criteria
Inclusion
- Women between 40-65 years of age
- Baseline handgrip strength \>20Kg
- Right-hand dominant
Exclusion
- Personal or family history of blood clots
- Current use of anticoagulant medications
- Neuromuscular or metabolic diseases (e.g., multiple sclerosis, diabetes)
- Arthritis
- Osteoporosis or osteopenia
- History of myocardial infarction within the past year
- Chronic pain ≥3/10 for ≥3 months
- Uncontrolled hypertension (≥140/90 mmHg)
- Upper extremity surgery within the past year
- Use of assistive hand or arm device within the past year
- Fall involving the upper extremities within the past year
- Upper extremity injuries preventing safe participation
- Use of body composition-altering medications (e.g., testosterone, GLP-1 agonists) in past 6 months
- Current use of muscle relaxants, benzodiazepines, or similar drugs
- Smoking within the past 6 months
- History of drug or alcohol abuse within the past year
- Severe anxiety or claustrophobia
- Pregnancy (current or planned)
- Allergies to medical adhesives
- High risk of sarcopenia (per SARC-F)
- Contraindications to TMS or MRI
- Not right-hand dominant
- Upper-body resistance training within the past 6 months
- Inability/unwillingness to refrain from resistance training during study
Key Trial Info
Start Date :
November 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 31 2026
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT07166198
Start Date
November 1 2025
End Date
May 31 2026
Last Update
September 17 2025
Active Locations (1)
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1
Neuromuscular Physiology Laboratory
Manhattan, Kansas, United States, 66506