Status:
RECRUITING
xDRIVE for Florida-based Cancer Patients
Lead Sponsor:
First Ascent Biomedical Inc.
Conditions:
Cancer
Neoplams
Eligibility:
All Genders
Phase:
NA
Brief Summary
Through this study funded by the Florida Cancer Innovation Fund, First Ascent will demonstrate state-wide feasibility of providing xDRIVE Functional Precision Medicine + Artificial Intelligence platfo...
Detailed Description
Cancer remains a leading cause of death in Florida, presenting formidable challenges across different patient populations resulting in over with 138,000 deaths in the previous 5 years. For children, c...
Eligibility Criteria
Inclusion
- Patients with recurrent/refractory cancer patients up to age 18 (willing to sign assent if ages 7 - 17 years)
- -OR- Patients with recurrent/refractory cancer ≥18 years of age.
- Patients who have received at least one prior line of standard of care therapy.
- Patients able to provide treatment and outcome information from previous line(s) of therapy.
- Patients with sufficient health status to undergo cancer therapy, e.g., Eastern Cooperative Group (ECOG) performance status of 0, 1, or 2 for adult patients.
- Patients who are scheduled for or have recently undergone a tumor biopsy, excision, or resection.
- Patients willing to have a blood draw or buccal swab performed for matched normal material for comparison during tumor DNA profiling.
Exclusion
- Patients who do not have malignant tissue available and accessible, patients where the amount of excised malignant tissue is insufficient material for ex vivo drug testing and/or genetic profiling, defined as \<0.3g for resections or core/fine-needle biopsies not containing malignant tissue by pathology review, or insufficient malignant tissue in peripheral blood or bone marrow aspirate samples.
- Patients with insufficient health indicators to undergo therapeutic intervention.
Key Trial Info
Start Date :
November 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2027
Estimated Enrollment :
210 Patients enrolled
Trial Details
Trial ID
NCT07167381
Start Date
November 1 2025
End Date
April 1 2027
Last Update
December 23 2025
Active Locations (2)
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1
First Ascent Biomedical
Miami, Florida, United States, 33183
2
Florida International University
Miami, Florida, United States, 33199