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Status:

NOT_YET_RECRUITING

Transfusion Exchanges and Cognition in Sickle Cell Disease

Lead Sponsor:

Centre Hospitalier St Anne

Conditions:

Drepanocytosis

Chronic Neurological Deficiency

Eligibility:

All Genders

18+ years

Brief Summary

DREPA-COG is an observational study evaluating the effect of exchange transfusions on cognitive function in adults with severe sickle cell disease (SS or Sβ0). Information processing speed is assessed...

Detailed Description

DREPA-COG is a non-interventional, multicenter observational study investigating the effect of exchange transfusions on cognitive performance in adults with severe sickle cell disease (SS or Sβ0). Cog...

Eligibility Criteria

Inclusion

  • Inclusion Criteria:
  • Adults (≥18 years) with severe sickle cell disease (SS or Sβ0).
  • Enrolled in a regular monthly transfusion exchange program.
  • Not institutionalized.
  • No known dementia.
  • No severe aphasia.
  • Affiliated with or beneficiary of a social security system.
  • Exclusion criteria:
  • Insufficient mastery of spoken French.
  • Severe comorbidities preventing short-term follow-up.
  • Known psychiatric disorders.
  • Participation in another clinical study with ongoing exclusion periods.
  • Lack of adequate computer equipment (minimum 11-inch screen and internet connection).
  • Vulnerable patients under legal protection (guardianship or curatorship).

Exclusion

    Key Trial Info

    Start Date :

    December 3 2025

    Trial Type :

    OBSERVATIONAL

    Allocation :

    ESTIMATED

    End Date :

    November 2 2027

    Estimated Enrollment :

    85 Patients enrolled

    Trial Details

    Trial ID

    NCT07168447

    Start Date

    December 3 2025

    End Date

    November 2 2027

    Last Update

    September 11 2025

    Active Locations (6)

    Enter a location and click search to find clinical trials sorted by distance.

    Page 1 of 2 (6 locations)

    1

    Assistance Publique - Hôpitaux de Paris Hôpital Avicenne

    Bobigny, Île-de-France Region, France, 93000

    2

    Hôpital Henri Mondor

    Créteil, Île-de-France Region, France, 94000

    3

    Hôpital Kremlin-Bicêtre

    Le Kremlin-Bicêtre, Île-de-France Region, France, 94 275

    4

    GHU Paris Psychiatrie et Neurosciences - Hôpital Sainte-Anne

    Paris, Île-de-France Region, France, 75014