Status:
RECRUITING
Study of the Pharmacokinetics of Ceftriaxone
Lead Sponsor:
University Hospital, Rouen
Conditions:
Urinary Infections
Eligibility:
All Genders
18+ years
Brief Summary
Urinary tract infections (UTIs) are the leading cause of community-acquired bacterial infections in adults. They are a common reason for admission to the Emergency Department (ED), particularly when p...
Detailed Description
While PK data in healthy volunteers support a single dose of ceftriaxone 1 gram/day, those from intensive care patients support 2 or even 4 grams/day. Febrile UTIs are a heterogeneous group of patient...
Eligibility Criteria
Inclusion
- Adult patient over 18 years of age
- Requiring hospitalization at Rouen University Hospital
- Clinical diagnosis of urinary tract infection requiring ceftriaxone antibiotic therapy
- Prescription of 1g IV ceftriaxone
- Venipuncture for laboratory testing as part of the prescribed treatment within 24 hours of the first ceftriaxone injection
- Patient has read and understood the information letter and given oral consent to participate in the study
Exclusion
- Minor patient
- Patient hospitalized in an intensive care unit
- Patient with septic shock
- Chronic dialysis or indication for emergency renal replacement therapy (ERP)
- Prescription of a dosage other than 1g intravenously per 24 hours
- Patient having received more than one injection of 1g ceftriaxone
- Pregnant, parturient, or breastfeeding woman
- Person deprived of liberty by an administrative or judicial decision
- Person placed under judicial protection, guardianship, or curatorship
Key Trial Info
Start Date :
September 30 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2027
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT07169097
Start Date
September 30 2024
End Date
May 1 2027
Last Update
September 11 2025
Active Locations (1)
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1
Rouen University Hospital
Rouen, France, 76031