Status:
RECRUITING
Screening of Biomarkers and Related Mechanisms for RIX
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University
Collaborating Sponsors:
The Tumor Hospital of Jiangsu Province
The First Affiliated Hospital with Nanjing Medical University
Conditions:
Xerostomia Due to Radiotherapy (Disorder)
Eligibility:
All Genders
18-75 years
Brief Summary
A large number of patients undergoing radiotherapy and chemotherapy are suffering from dry mouth. Due to reduced saliva secretion, patients may experience symptoms such as difficulty chewing and swall...
Eligibility Criteria
Inclusion
- Histological diagnosis of head and neck cancer;
- Plan to undergo curative treatment with radiotherapy alone or in combination with synchronous chemotherapy, immunotherapy, or targeted therapy;
- Age greater than or equal to 18 years old, Fully understand the purpose and significance of this study, voluntarily participate and sign an informed consent form.
Exclusion
- Metastatic diseases;
- History of head and neck radiotherapy;
- Severe dry mouth before radiotherapy;
- Suffering from advanced chronic diseases: heart failure - New York Heart Association functional classification III/IV, renal failure - estimated glomerular filtration rate under 30mL/min/1.73m2, liver failure - Child Pugh score C or D.
Key Trial Info
Start Date :
May 17 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
126 Patients enrolled
Trial Details
Trial ID
NCT07170358
Start Date
May 17 2024
End Date
December 31 2026
Last Update
September 12 2025
Active Locations (4)
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1
The First Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China, 210018
2
Affiliated Jinling Hospital, Medical School of Nanjing University
Nanjing, Jiangsu, China
3
Jiangsu Cancer Hospital
Nanjing, Jiangsu, China
4
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China