Status:
NOT_YET_RECRUITING
What is the Role of the Exposome in Pulmonary Hypertension
Lead Sponsor:
Poitiers University Hospital
Conditions:
Pulmonary Arterial Hypertension (PAH)
Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Eligibility:
All Genders
18+ years
Brief Summary
Pulmonary arterial hypertension (PAH) is a rare and incurable disease affecting people of all ages. It is characterized by obstructive remodeling of the small pulmonary arteries, responsible for an in...
Eligibility Criteria
Inclusion
- Consent signed by the participant
- Age ≥ 18 years
- Free subject, under no legal protection
- Good understanding of the French language, allowing to answer the questionnaires
- Incident patients with pre-capillary PH confirmed by cardiac catheterization (PAPm \> 20mmHg, PCP ≤ 15 mmHg, RVP \> 2UW) having had the right diagnostic cardiac catheterization within one year (≤1 year) :
- Cases: Patients with PAH without associated pathology: idiopathic or heritable, or with features of venous/capillary involvement, according to the clinical classification of PH
- Controls: Patients with chronic thromboembolic PH (CTE-PTH, class 4), according to the clinical classification of PH.
Exclusion
- Patients classified as HTP groups 2, 3 or 5
- Patients with a diagnosis of PAH associated with a connective tissue disease, HIV, portal hypertension, congenital heart disease, bilharzia, or a drug or toxic cause considered certain according to the international classification (Aminorex, Benfluorex, Carfilzomib, Dasatinib, Dexfenfluramine, Fenfluramine, Methamphetamines, Mitomycin C, adulterated rapeseed oil)
- Patients with signs of right heart failure requiring amines and/or intensive care hospitalization at time of visit (may be included at a later visit)
- Patients refusing hair sampling or having no hair \> 2 cm to allow sampling
- Patients benefiting from enhanced protection, i.e. minors, persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social establishment, adults under legal protection, and patients in emergency situations
Key Trial Info
Start Date :
December 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2027
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT07172334
Start Date
December 1 2025
End Date
December 1 2027
Last Update
September 15 2025
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.