Status:
COMPLETED
The Effect of Using Octenidine Hydrochloride as a Final Irrigation Solution on Teeth With Asymptomatic Apical Periodontitis on Postoperative Pain and Treatment Success: A Prospective Randomized Clinical Study
Lead Sponsor:
Bezmialem Vakif University
Conditions:
Apical Periodontitis
Postoperative Pain
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
This single-centre, randomized, parallel-group clinical trial compared two commonly used final irrigants in single-visit root canal treatment: octenidine dihydrochloride (OCT) and chlorhexidine (CHX)....
Detailed Description
Design and setting. Prospective, randomized, parallel-group, blinded clinical trial conducted at a university dental hospital (Istanbul, Turkey). All treatments were completed in a single visit by an ...
Eligibility Criteria
Inclusion
- Adults aged 18 to 65 years (inclusive)
- Single-rooted, single-canal tooth
- Diagnosis of asymptomatic apical periodontitis on periapical radiographs
- Able and willing to provide written informed consent
- Able to complete a 48-hour pain diary (6 h, 12 h, 24 h, 48 h)
Exclusion
- Symptomatic apical periodontitis or acute apical abscess
- Previous root canal treatment of the study tooth
- Systemic condition requiring antibiotic prophylaxis or that interferes with pain assessment
- Pregnancy or lactation
- Known allergy or contraindication to study irrigants/materials
- Use of analgesics or anti-inflammatory drugs within 12 hours before treatment
- Inability to comply with study procedures
- More than one eligible tooth (one patient = one tooth rule; a pre-specified index tooth is selected)
Key Trial Info
Start Date :
March 8 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 20 2025
Estimated Enrollment :
142 Patients enrolled
Trial Details
Trial ID
NCT07173725
Start Date
March 8 2023
End Date
July 20 2025
Last Update
September 15 2025
Active Locations (1)
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1
Bezmialem Vakif University Dental Hospital - Department of Endodontics
Istanbul, Turkey (Türkiye), 34093