Status:
NOT_YET_RECRUITING
Rocklatan Retinal Perfusion OCT Study
Lead Sponsor:
Oregon Health and Science University
Collaborating Sponsors:
Alcon Research
Conditions:
Glaucoma
Eligibility:
All Genders
21+ years
Phase:
PHASE4
Brief Summary
The main purpose of this study is to learn more about how Rocklatan eye drops affects blood flow in the eye. The secondary purpose is to see if our study devices can detect changes in blood flow befor...
Eligibility Criteria
Inclusion
- Patients with both eyes with open angle glaucoma.
- Abnormal VF (glaucomatous pattern with PSD abnormal at p\<0.05 or GHT outside normal limits) on most recent two clinic visits on chart review
- Glaucomatous disc abnormality on chart review and confirmed on baseline disc photograph
- Overall average NFL thickness \> 55 μm measured by Heidelberg Spectralis OCT -Glaucoma Module Premium Edition (chart review), consistent with early glaucoma
- NFLP-CD deficit (below 5 percentile of normal) in any of the 8 sectors on the initial baseline visit
- The difference in baseline NFLP-CD between the left and right eye should be less than 5% (% of area).
- IOP \>= 17 mm Hg on the most recent two clinic visits (chart review) after monotherapy with latanoprost in both eyes.
Exclusion
- Best corrected visual acuity worse than 20/30 on chart review of most recent clinic visit
- Age \< 21 years at baseline
- Eye disease that could affect VF, NFL thickness, or NFLP (e.g., visually significant cataract, AMD, diabetic retinopathy, and optic neuropathy) at any study visit
- OCT and OCTA scans not meeting quality criteria at baseline
- Inability to cooperate with study procedures
- Inability to commit to the study visits
Key Trial Info
Start Date :
January 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2027
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT07174401
Start Date
January 1 2026
End Date
October 1 2027
Last Update
December 24 2025
Active Locations (1)
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1
Casey Eye Institute - Oregon Health & Science University
Portland, Oregon, United States, 97239