Status:
RECRUITING
7T Brain MRI Scan for Micro-brain Metastasis (microBM) Detection for Patients With Small-cell Lung Cancer (SCLC), Who Decline Prophylactic Cranial Irradiation (PCI)
Lead Sponsor:
University of Missouri-Columbia
Collaborating Sponsors:
Siemens Medical Solutions
Conditions:
Small-cell Lung Cancer
Brain Metastases
Eligibility:
All Genders
18+ years
Brief Summary
Comparison of a 7t MRI to standard of care 1.5t/3t MRI scans to determine if earlier detection of brain metastases are possible on a 7t.
Detailed Description
This study is looking at patients diagnosed with small-cell lung cancer \& have declined prophylactic cranial irradiation. Patients must have had a 1.5t/3t MRI performed within 4 weeks of consenting t...
Eligibility Criteria
Inclusion
- Patient must have a histologically confirmed diagnosis of small-cell lung cancer (SCLC). • Patient must have an MRI of the brain, performed within 4 weeks prior to consent, documenting no evidence of brain metastases or leptomeningeal disease.
- Patient also must not have a history of brain metastases or leptomeningeal disease.
- Patient must refuse PCI and agree to surveillance with brain MRI scans (1.5T/3T).
- Patient must be ≥ 18 years of age.
- Patient must have ECOG Performance Status of 0-2
- Patients must be able to tolerate the 7T MRI
Exclusion
- Patient must not have a contraindication to an MRI, such as implanted metal devices or foreign bodies.
- Patient must not have a contraindication to gadolinium contrast administration during MR imaging.
- Patient must not have other metastatic malignancies requiring current active treatment.
- Pregnant patients are excluded. Pregnancy status will be confirmed verbally.
Key Trial Info
Start Date :
November 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2027
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT07175077
Start Date
November 1 2025
End Date
September 1 2027
Last Update
December 2 2025
Active Locations (1)
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1
University of Missouri
Columbia, Missouri, United States, 65212