Status:
NOT_YET_RECRUITING
Holy Basil in The Treatment of Dyspepsia
Lead Sponsor:
Mahidol University
Conditions:
Dyspepsia and Other Specified Disorders of Function of Stomach
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
The goal of this clinical trial is to evaluate whether holy basil extract can reduce gastric inflammation and improve symptoms in adult patients with dyspepsia. The main questions it aims to answer a...
Detailed Description
Functional dyspepsia is a common condition that causes chronic upper abdominal discomfort, bloating, and early satiety in the absence of structural disease. Conventional therapies such as acid suppres...
Eligibility Criteria
Inclusion
- Participants aged 18 years and older.
- Presence of dyspeptic symptoms, assessed by the Leeds Dyspepsia Questionnaire with a score of at least 5 or higher.
Exclusion
- Presence of Helicobacter pylori infection.
- Diagnosis of peptic ulcer or erosive esophagitis Los Angeles Classification grade B or greater.
- Use of acid-suppressant therapy including proton pump inhibitors (PPIs) or histamine-2 receptor antagonists (H2RAs) that cannot be discontinued at least 2 weeks prior enrolment and during the study period.
- Use of mucosal protective agents, such as rebamipide, sucralfate, or irsogladine that cannot be discontinued at least 4 weeks prior enrolment and during the study period.
- History of gastric cancer or duodenal cancer.
- Previous upper gastrointestinal surgery.
- Current pregnancy or lactation.
- Known allergic to the medicine.
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT07175272
Start Date
October 1 2025
End Date
December 1 2026
Last Update
September 16 2025
Active Locations (1)
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1
Faculty of Medicine Siriraj Hospital, Mahidol University
Bangkok Noi, Bangkok, Thailand, 10700