Status:
RECRUITING
Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)
Lead Sponsor:
The University of Texas Health Science Center at San Antonio
Collaborating Sponsors:
United States Department of Defense
Conditions:
Posttraumatic Stress Disorder
PTSD
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
By doing this research project, the investigators hope to learn which strategies work best to help veterans who are not benefiting from their first PTSD treatment or not completing between-session hom...
Detailed Description
This study is designed to assist the investigators in answering the clinical question of how to address non-response to first line PTSD treatments. Utilizing an innovative Hybrid Experimental Design (...
Eligibility Criteria
Inclusion
- Veterans eligible for PE and CPT at the participating PTSD treatment-providing clinic who are
- At least 18 years or older
- Score ≥ 31 on the PCL-5 secondary to a Criterion A traumatic event
- Own a mobile device that can be used for the therapy companion mobile app (Prolonged Exposure (PE) coach or Cognitive Processing Therapy (CPT) coach).
Exclusion
- Acute suicide risk requiring clinical intervention
- Need for detoxification
- Unmanaged psychosis or bipolar disorder
- Severe cognitive impairment that makes it unlikely that participants can adhere to the study regimen (as evidenced by confusion, inability to track discussion or answer questions, or other clear and significant indicators of cognitive impairment)
- Current or past 12-month engagement in PE or CPT.
Key Trial Info
Start Date :
December 12 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 14 2028
Estimated Enrollment :
302 Patients enrolled
Trial Details
Trial ID
NCT07176273
Start Date
December 12 2025
End Date
August 14 2028
Last Update
December 19 2025
Active Locations (4)
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1
Augusta VA
Augusta, Georgia, United States, 30904
2
Ann Arbor VA
Ann Arbor, Michigan, United States, 48105
3
Battle Creek VA
Battle Creek, Michigan, United States, 49037
4
Salt Lake City VA
Salt Lake City, Utah, United States, 84148