Status:
NOT_YET_RECRUITING
The PRE-VAIL Study
Lead Sponsor:
The First Hospital of Jilin University
Conditions:
ARDS (Moderate or Severe)
Prone Position
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
During the prone position, there may be an increase in intragastric pressure. The investigators focus on a scientific question: Whether reducing enteral nutrition before the prone position will benefi...
Detailed Description
During the prone position, there may be an increase in intragastric pressure. The investigators focus on a scientific question: Whether reducing enteral nutrition before the prone position will benefi...
Eligibility Criteria
Inclusion
- Age ≥18 years old
- Within 24 hours of admission to the ICU, one or more organ systems have failed (the Sequential Organ Failure Assessment (SOFA) score of any single organ system is ≥2)
- Meet the diagnostic criteria for moderate/severe ARDS (even after optimizing the ventilation Settings, the oxygenation index is still \< 150mmHg and PEEP is still ≥5 cm H2O)
- It is expected to stay in the ICU for more than 48 hours
Exclusion
- There are contraindications for the prone position
- There are contraindications for EN, preventing the initiation of early EN (≤48 hours)
- Expected to die within 48 hours
- Pregnancy
Key Trial Info
Start Date :
December 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 20 2028
Estimated Enrollment :
259 Patients enrolled
Trial Details
Trial ID
NCT07176624
Start Date
December 1 2025
End Date
February 20 2028
Last Update
December 4 2025
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