Status:
NOT_YET_RECRUITING
TNF-α Antagonists Mitigate Systemic Inflammatory Response After Cardiac Arrest.
Lead Sponsor:
Peking University Third Hospital
Collaborating Sponsors:
Peking University First Hospital
Peking University People's Hospital
Conditions:
Cardiac Arrest (CA)
Post Cardiac Arrest Syndrome
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The investigators assessed the effect of TNF-α antagonism within 6 hours of return of spontaneous circulation on 30-day mortality in patients who remained comatose after cardiopulmonary resuscitation ...
Eligibility Criteria
Inclusion
- Patients aged ≥18 years;
- Patients with suspected cardiogenic cardiac arrest;
- Patients with comatose state after ROSC (Glasgow Coma Scale \[GCS\] score \<9);
- Patients with Return of spontaneous circulation (ROSC) sustained for \>20 minutes;
Exclusion
- Cardiac arrest due to trauma;
- Suspected or confirmed hemorrhagic or ischemic stroke;
- Pregnancy;
- Cardiac arrest without witnessed collapse;
- Admission body temperature \<30°C;
- Persistent cardiogenic shock (defined as systolic blood pressure \<90 mmHg despite aggressive intervention during screening);
- Any underlying disease with an expected survival of \<180 days;
- Pre-existing severe neurological dysfunction before cardiac arrest (e.g., Cerebral Performance Category \[CPC\] 3-4);
- Time from ROSC to randomization exceeding 4 hours;
- Left ventricular ejection fraction (LVEF) \<35% after ROSC;
- Known hypersensitivity to TNF-α antagonist components;
- Known tuberculosis or other active infections;
- Known poor prognosis (as determined by the investigator);
- History of liver cirrhosis;
- History of chronic heart failure with NYHA functional class III-IV.
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 31 2028
Estimated Enrollment :
208 Patients enrolled
Trial Details
Trial ID
NCT07176754
Start Date
October 1 2025
End Date
October 31 2028
Last Update
September 16 2025
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.