Status:
NOT_YET_RECRUITING
Primary Ureteroscopy for Acute Obstructive Nephropathy Due to Ureteral Stones: A Prospective Non-randomized Feasibility and Safety Trial
Lead Sponsor:
Assiut University
Conditions:
Acute Obstructive Nephropathy
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Ureteroscopy (URS) is a widely used minimally invasive procedure for the management of ureteral and renal stones (1). While the procedure is generally safe and effective, patient factors such as renal...
Eligibility Criteria
Inclusion
- • Adults (\>18 years) with acute unilateral ureteral obstruction confirmed by:
- Non-contrast CT (stone size ≥5mm)
- Hydronephrosis on ultrasound
- Planned for primary URS (no prior stenting/nephrostomy)
- Renal function eligibility:
- Acute deterioration (elevated serum Cr and urea) serum creatinine ≥1.3 mg/dL but less than 5 mg/dL
Exclusion
- • Systemic contraindications to URS:
- Uncorrected coagulopathy (INR \>1.5)
- Active UTI/sepsis (requiring drainage-first approach)
- Severe cardiopulmonary compromise (ASA class ≥IV)
- Patients with hypercalcemia.
- hyperkalemia \>6.5 mEq/L
- Metabolic acidosis (pH \<7.1)
- Patients with pulmonary edema.
- Patients with uremic encephalopathy.
- Bilateral obstruction
- Known ureteral stricture distal to stone
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT07177313
Start Date
October 1 2025
End Date
December 1 2026
Last Update
September 24 2025
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