Status:
ACTIVE_NOT_RECRUITING
A Study of the Impact of Penicillin Allergy on Antimicrobial Resistance and ouTcomes
Lead Sponsor:
University of Leeds
Conditions:
Penicillin Allergy
Antimicrobial Drug Resistance
Eligibility:
All Genders
16+ years
Brief Summary
Penicillin allergy is one of the commonest reported allergies. The presence of a penicillin allergy record in a patients notes leads to the avoidance of recommended first-line penicillin antibiotics a...
Detailed Description
Study hypothesis: Patients with a penicillin allergy record are more likely to have resistance to non-penicillin antibiotics in their normal flora and that this will increase their risk of treatment ...
Eligibility Criteria
Inclusion
- Workstream 1
- Adult (\>16 years) with confirmed COVID-19 (positive PCR test)
- Admitted to participating NHS Trusts/hospitals between 01/02/2020 to 30/06/2020
- Workstream 2
- Adult (≥18 years) patients with a penicillin allergy or a matched patients (by age and sex) without a penicillin allergy
- Received antibiotics in the 24 months prior to recruitment
- Willing to provide saliva +/- stool samples
- Workstream 3
- Patients enrolled into the ALABAMA trial
Exclusion
- Workstream 1
- a. Patients with their allergy status missing will be excluded.
- Workstream 2
- Patients unable to give informed consent or who are unwilling/unable to provide saliva samples
- Unwilling/unable to provide saliva samples
- Workstream 3
- Patients unable to give informed consent or who are unwilling/unable to provide saliva samples
- Unwilling/unable to provide saliva samples
Key Trial Info
Start Date :
November 30 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2025
Estimated Enrollment :
214 Patients enrolled
Trial Details
Trial ID
NCT07177690
Start Date
November 30 2021
End Date
December 1 2025
Last Update
September 17 2025
Active Locations (1)
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1
Leeds Teaching Hospitals NHS trust
Leeds, United Kingdom