Status:
NOT_YET_RECRUITING
Assessment of Structural Brain Changes Related to Anoxic Coma Using High-field and Very Low Field Mobile MRI
Lead Sponsor:
University Hospital, Toulouse
Collaborating Sponsors:
National Research Agency, France
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Anoxic Coma
Cardiac Arrest (CA)
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Standard predictors of outcome after cardiac arrest (CA) have substantial limitations in terms of reliability and generalizability. By providing brain structural connectivity maps, or connectomes, adv...
Detailed Description
About two-thirds of patients who are in coma after resuscitation from cardiac arrest (CA) die before hospital discharge, of whom two-thirds die from neurological injury. However, only a minority of th...
Eligibility Criteria
Inclusion
- Inclusion criteria :
- COMA PATIENTS
- Adult patients (male or female ≥ 18 years).
- Coma, as indicated by a Glasgow Coma Scale (GCS) ≤ 8 (motor score ≤ 2) immediately after CA resuscitation and before sedation onset.
- Written informed consent from patient's legal representative.
- Affiliation to the French social security system
- HEALTHY VOLUNTEERS
- Adult patients (male or female ≥ 18 years).
- Written informed consent.
- Affiliation to the French social security system
- Exclusion criteria :
- COMA PATIENTS
- Brain death.
- Coma explained by other cause than CA.
- Pregnancy.
- MRI contraindication: medical material not MRI compatible.
- Hemodynamic instability or respiratory failure precluding patient's transport and MRI scanning.
- HEALTHY VOLUNTEERS
- Pregnancy.
- MRI contraindication: medical material not MRI compatible.
- Volunteers who do not wish to be informed of an abnormality detected on MRI a posteriori
Exclusion
Key Trial Info
Start Date :
September 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2029
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT07177755
Start Date
September 15 2025
End Date
March 1 2029
Last Update
September 17 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
CHU de Toulouse
Toulouse, France