Status:
RECRUITING
Effects of Wild Blueberry Consumption on Brain Function in Elderly
Lead Sponsor:
Maastricht University Medical Center
Collaborating Sponsors:
Wild Blueberry Association of North America
Conditions:
Brain Insulin-sensitivity
Brain Vascular Function
Eligibility:
All Genders
60-75 years
Phase:
NA
Brief Summary
Impaired brain vascular function precedes the development of reduced cognitive performance, while brain insulin-resistance is associated with cognitive decline. Evidence from epidemiological studies h...
Eligibility Criteria
Inclusion
- Men and women, aged between 60-75 years
- BMI between 25-35 kg/m2 (overweight or obese)
- Fasting plasma glucose \< 7.0 mmol/L
- Fasting serum total cholesterol \< 8.0 mmol/L
- Fasting serum triacylglycerol \< 4.5 mmol/L
- Systolic blood pressure \< 160 mmHg and diastolic blood pressure \< 100 mmHg
- Stable body weight (weight gain or loss \< 3 kg in the past three months)
- Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study.
- No difficult venipuncture as evidences during the screening visit.
Exclusion
- Allergy or intolerance to berries
- Left-handedness
- Current smoker, or smoking cessation \< 12 months
- Diabetic patients
- Familial hypercholesterolemia
- Abuse of drugs
- More than 3 alcoholic consumptions per day
- Use of products or dietary supplements known to interfere with the main outcomes as judged by the principal investigators
- Use medication to treat blood pressure, lipid, or glucose metabolism
- Use of an investigational product within another biomedical intervention trial within the previous 1-month
- Severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases, and rheumatoid arthritis.
- Active cardiovascular disease like congestive heart failure or cardiovascular event, such as an acute myocardial infarction or cerebrovascular accident.
- Contra-indications for MRI imaging (e.g., pacemaker, surgical clips/material in body, metal splinter in eye, claustrophobia)
Key Trial Info
Start Date :
December 5 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2026
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT07177781
Start Date
December 5 2024
End Date
August 31 2026
Last Update
September 17 2025
Active Locations (1)
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1
Maastricht University, Departement of Nutrition and Movement Sciences
Maastricht, Limburg, Netherlands, 6200 MD