Status:
RECRUITING
Human Skeletal Muscle Response to 5 Days of Bedrest in Young Adults
Lead Sponsor:
Queen's University
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Conditions:
Muscular Atrophy
Insulin Resistance
Eligibility:
All Genders
18-30 years
Phase:
NA
Brief Summary
The goal of this intervention trial is to characterize skeletal muscle atrophy in healthy, young adults during short term bedrest. The main questions it aims to answer are: How much do skeletal muscl...
Detailed Description
Skeletal muscle plays a critical role in physical function and metabolic health, with its maintenance driven by the balance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB). D...
Eligibility Criteria
Inclusion
- Males and females 18-30 years
- BMI between 18.5-28 kg/m2
- Weight stable (within ±2kg for 6 months)
- Generally healthy as assessed by medical and physical activity questionnaires
- recreationally active
Exclusion
- a BMI \< 18.5 and \> 28 kg/m2
- the use of insulin to control blood glucose levels
- a history of any cardiovascular, respiratory, metabolic diseases, neuromuscular or bone-wasting diseases
- the use of any medication that may affect muscle protein turnover (e.g. androgen or anabolic hormone therapy, chemotherapy)
- a (family) history of thrombosis, platelet or coagulation disorders, or antiplatelet therapy and the use of anticoagulant medications
- the presence of any unremoved, or partially removed metals underneath the skin
- a history of head or eye injury involving metal fragments
- have some type of implanted electrical device (such as a cardiac pacemaker or neurostimulator)
- have implanted metal objects as a result of surgery, such as artificial joints, aneurysm clips, metal staples
- are, or may be, pregnant
- are wearing metal braces on their teeth.
Key Trial Info
Start Date :
September 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2027
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT07178353
Start Date
September 1 2025
End Date
June 1 2027
Last Update
September 22 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Queen's Univeristy
Kingston, Ontario, Canada, K7L 3N6