Status:
NOT_YET_RECRUITING
Double Plasma Separation and Adsorption in Acute-on-Chronic Liver Failure (DPMAS-ACLF Trial)
Lead Sponsor:
Institute of Liver and Biliary Sciences, India
Conditions:
Acute-on-Chronic Liver Failure (ACLF)
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Acute-on-chronic liver failure (ACLF) is a serious condition in which patients with chronic liver disease suddenly develop severe liver injury, leading to inflammation, organ failure, and very high sh...
Detailed Description
Acute-on-chronic liver failure (ACLF) is characterized by acute deterioration of liver function in patients with chronic liver disease, leading to systemic inflammation, organ failure, and high short-...
Eligibility Criteria
Inclusion
- ACLF patients of any etiology with systemic inflammatory response syndrome and AARC grade II or more.
Exclusion
- Patients eligible for corticosteroids for severe alcohol-associated hepatitis related ACLF (other than hydrocortisone according to Surviving Sepsis Campaign Guidelines 2021 which is 50 mg iv q 6 h for management of refractory shock
- Hepatocellular carcinoma or any extrahepatic malignancy,
- Active fungal sepsis
- Disseminated intravascular coagulation
- Hemodynamic instability requiring norepinephrine \>0.20ug/kg/min
- Patients with coma of non-hepatic origin
- Patients with PaO2/FiO2 ratio \<150
- Pregnancy
- Comorbidities associated with poor outcomes (severe cardiopulmonary disease defined by a New York Heart Association score \>3, or oxygen/steroid-dependent chronic obstructive pulmonary disease, chronic kidney disease) and patients with post-resection liver failure
- Patients with fibrinogen \<110 and/or platelets less than 50,000
- Patients with oliguria with urine output less than 400 ml/day
- Lack of informed consent
- Patient enrolled in other clinical trials
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2027
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT07178366
Start Date
October 1 2025
End Date
October 1 2027
Last Update
September 24 2025
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