Status:
RECRUITING
Randomized Controlled Trial of Berberine in Combination With Doxycycline in the Treatment of Chronic Endometritis
Lead Sponsor:
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Conditions:
Chronic Endometritis
Eligibility:
FEMALE
20+ years
Phase:
PHASE1
PHASE2
Brief Summary
Study Subjects: Eligible patients were initially diagnosed with chronic endometritis (CE) by CD138 testing through outpatient hysteroscopy. Positive CD138 expression is defined as at least one or more...
Detailed Description
Grouping: The patients were randomly divided into the experimental group and the control group by a simple numerical table method, with a ratio of 1:1. * Patients in the experimental group were treat...
Eligibility Criteria
Inclusion
- Diagnosis of chronic endometritis by CD138 immunohistochemistry; Age≥ 20 years old, females of childbearing age; Agree to undergo hysteroscopy and hysteroscopic endometrial biopsy; No serious systemic disease; There are no contraindications to oral administration of doxycycline hydrochloride and berberine hydrochloride.
Exclusion
- Patients with pregnancy status, uterine malignant disease, hormone therapy within 3 months, glucose-6 phosphate dehydrogenase deficiency, hemolytic anemia, hypersensitivity to berberine hydrochloride or doxycycline. In addition, berberine hydrochloride has fewer oral adverse reactions, occasional nausea and vomiting, rash and drug fever, which disappear after stopping the drug. If the patient takes the wrong or missed medication, it is excluded.
Key Trial Info
Start Date :
March 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
206 Patients enrolled
Trial Details
Trial ID
NCT07180563
Start Date
March 15 2025
End Date
December 31 2026
Last Update
September 18 2025
Active Locations (1)
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1
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Yiwu, Zhejiang, China, 322000