Status:
NOT_YET_RECRUITING
Urine Pneumococcal Antigen Project
Lead Sponsor:
Liverpool School of Tropical Medicine
Collaborating Sponsors:
Malawi Liverpool Wellcome Programme
Conditions:
Pneumonia
Pneumonia - Bacterial
Eligibility:
All Genders
12-24 years
Brief Summary
Background:Pneumonia caused by the bacteria Streptococcus pneumoniae is a leading cause of death among children under five years of age, especially in sub-Saharan Africa. Accurate diagnosis remains ch...
Detailed Description
Study type: This is a nested case-control sub-study within the multi-site, observational NP Resistome study (COMREC reference P.10/24-1200). Background: Pneumococcal pneumonia is a leading cause of ...
Eligibility Criteria
Inclusion
- Inclusion criteria for healthy children in the community
- • Child aged between12-24 months.
- Exclusion criteria for healthy children in the community
- Presence of any of the following symptoms: fever, cough, difficulty in breathing or fast breathing.
- Currently taking long-term antibiotic prophylaxis, TB treatment or immunosuppressive medications.
- Diagnosis of an immunosuppressive illness, including HIV infection.
- Hospital admission within the past six months.
- Inclusion criteria for children with pneumonia in the community
- Child aged between12-24 months.
- Presence of all of the following symptoms: fever, cough, difficulty in breathing and fast breathing.
- Participant has been prescribed antibiotics for treatment of a lower respiratory tract infection on this presentation.
- Exclusion criteria for children with pneumonia in the community
- Severe anaemia, with a recorded haemoglobin level \< 70 grams per Litre.
- Currently taking long-term antibiotic prophylaxis, TB treatment or immunosuppressive medications.
- Diagnosis of an immunosuppressive illness, including HIV infection.
- Hospital admission within the past six months.
- Inclusion criteria for children hospitalised with pneumonia
- Child aged between 12-24 months.
- Presence of all of the following symptoms: fever, cough, difficulty in breathing and fast breathing.
- Participant has been prescribed antibiotics for treatment of a lower respiratory tract infection on this presentation.
- Exclusion criteria for children hospitalised with pneumonia
- Severe anaemia, with a recorded haemoglobin level \< 70 grams per Litre.
- Currently taking long-term antibiotic prophylaxis, TB treatment or immunosuppressive medications.
- Diagnosis of an immunosuppressive illness, including HIV infection.
- Hospital admission within the past six months.
- Inclusion criteria for children re-hospitalised with pneumonia
- Child aged between12-24 months.
- Presence of all of the following symptoms: fever, cough, difficulty in breathing and fast breathing.
- Participant has been prescribed antibiotics for treatment of a lower respiratory tract infection on this presentation.
- Hospital admission to ANY hospital with a lower respiratory tract infection within the past 3 months.
- Exclusion criteria for children re-hospitalised with pneumonia
- Severe anaemia, with a recorded haemoglobin level \< 70 grams per Litre.
- Currently taking long-term antibiotic prophylaxis, TB treatment or immunosuppressive medications.
- Diagnosis of an immunosuppressive illness, including HIV infection.
Exclusion
Key Trial Info
Start Date :
October 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2027
Estimated Enrollment :
350 Patients enrolled
Trial Details
Trial ID
NCT07181200
Start Date
October 1 2025
End Date
August 1 2027
Last Update
September 18 2025
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