Status:
COMPLETED
High-Frequency vs. Theta-Burst TMS for Depression
Lead Sponsor:
Krajská zdravotní, a.s. - Nemocnice Most, o.z.
Conditions:
Major Depression
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
The goal of this clinical trial was to learn if two different types of repetitive transcranial magnetic stimulation (rTMS) could help treat depression and anxiety in adults with major depressive disor...
Detailed Description
This randomized, double-blind clinical trial evaluated two established repetitive transcranial magnetic stimulation (rTMS) protocols-high-frequency rTMS (HF-rTMS) and intermittent theta-burst stimulat...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Adults aged 18 to 90 years.
- Current major depressive disorder (MDD) as the primary diagnosis, confirmed according to the International Classification of Diseases, 10th Revision (ICD-10).
- All participants had to be evaluated by a board-certified psychiatrist trained in rTMS to confirm eligibility.
- Ability and willingness to provide written informed consent prior to study participation.
- Exclusion Criteria
- Presence of ferromagnetic or electronic implants in the head or neck (e.g., pacemakers, aneurysm clips, cochlear implants, deep brain stimulators).
- Known seizure disorders (such as epilepsy) or significantly increased risk of seizures.
- Other major neurological diseases or conditions that would interfere with safe rTMS administration.
- Active psychotic symptoms or a primary psychotic disorder.
- Acute manic episode or recent hospitalization for mania or other severe psychiatric instability.
- Ongoing electroconvulsive therapy (ECT) treatment.
- Medication changes made during the study.
- Inability to comply with the treatment schedule (e.g., attendance problems, logistical barriers).
- Any medical or psychiatric condition judged by the investigators to compromise safety or data integrity.
Exclusion
Key Trial Info
Start Date :
May 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 30 2025
Estimated Enrollment :
108 Patients enrolled
Trial Details
Trial ID
NCT07181226
Start Date
May 1 2022
End Date
April 30 2025
Last Update
September 24 2025
Active Locations (1)
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1
Krajská zdravotní, a.s. - Nemocnice Most, o.z.
Most, Ústecký kraj, Czechia, 434 64