Status:
RECRUITING
Effects of Long-term Remote Ischemic Preconditioning on Clinical Outcome in Patients With Acute Myocardial Infarction
Lead Sponsor:
Henan Institute of Cardiovascular Epidemiology
Conditions:
Acute Myocardial Infarction
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
At present, there are 290 million cardiovascular patients in China, including 11 million patients with coronary heart disease. Remote ischemic preconditioning(RIPC) may play an effective endogenous ca...
Detailed Description
A total of 2146 patients with AMI are expected included as the research objects and randomly divided into experimental group and control group with 1073 cases in each group. After admission, Patients ...
Eligibility Criteria
Inclusion
- Patients with acute myocardial infarction were diagnosed in accordance with the criteria of the "Global Unified Definition of Fourth Myocardial Infarction"
Exclusion
- The patients could not tolerate RIPC or RIPerC
- Aortic dissection, coronary artery aneurysm, coronary artery fistula and other systemic organic diseases
- The uncontrolled systolic blood pressure and diastolic blood pressure of severe hypertension were 180 mmHg and 120 mmHg respectively
- severe liver dysfunction (bilirubin \> 20 mmol / L, prothrombin time \> 2.0 ratio)
- Severe renal insufficiency (GFR \< 30 ml / min / 1.73 m2);
- patients taking nicorandil and other drugs affecting microcirculation
- pregnant
Key Trial Info
Start Date :
January 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2028
Estimated Enrollment :
2146 Patients enrolled
Trial Details
Trial ID
NCT07181356
Start Date
January 1 2025
End Date
December 1 2028
Last Update
September 18 2025
Active Locations (1)
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1
Fuwai Central China Cardiovascular Hospital
Zhengzhou, Henan, China, 450000