Status:
COMPLETED
Hypoxia and Kynurenine Pathway in Periodontal Inflammation
Lead Sponsor:
Istanbul Medipol University Hospital
Collaborating Sponsors:
Ankara University
Conditions:
Periodontitis
Diagnose Disease
Eligibility:
All Genders
18-65 years
Brief Summary
The kynurenine pathway (KP), the primary route for tryptophan (TRP) metabolism, is activated during inflammation and hypoxic conditions, contributing to immune dysregulation and oxidative stress. the ...
Detailed Description
Systemically healthy 23 stage III, grade B periodontitis patients and 22 periodontally healthy individuals were included in this study. Salivary and serum tumor necrosis factor-alpha (TNF-α), hypoxia-...
Eligibility Criteria
Inclusion
- systemically healthy
- clinical diagnosis of periodontitis
- clinical diagnosis of periodontal health
Exclusion
- decline to participate and being under 18 \& over 65 years of age;
- having any systemic inflammatory diseases such as diabetes, rheumatoid arthritis, or systemic conditions, including immunodeficiency syndrome, cardiovascular disorders, or hepatic disorders;
- the use of antibiotics and/or anti-inflammatory nonsteroidal anti-inflammatory drugs within 3 months preceding the study;
- having nonsurgical periodontal treatment (previous 6 months);
- having surgical periodontal treatment (previous 12 months);
- having \<20 natural teeth excluding the third molars.
Key Trial Info
Start Date :
February 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 22 2024
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT07182448
Start Date
February 1 2023
End Date
August 22 2024
Last Update
September 19 2025
Active Locations (1)
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1
Istanbul Medipol University
Istanbul, Turkey (Türkiye)