Status:
COMPLETED
Healing of Intrabony Defects Following Treatment With PRF or EMD
Lead Sponsor:
Semmelweis University
Conditions:
Periodontal Bone Loss
Periodontal Disease
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Objective: To evaluate clinically the long-term results following treatment of deep intrabony defects with either platelet-rich fibrin gel (PRF) or an enamel matrix derivative (EMD). Methods: Twenty ...
Eligibility Criteria
Inclusion
- No systemic conditions affecting treatment outcomes
- Good oral hygiene \[plaque index (PI) \<1; Löe 1967\]
- Compliance with the maintenance program
- Presence of at least one intra-bony defect with a probing depth (PD) of ≥6 mm and an intra-bony component of ≥3 mm confirmed by radiographs.
Exclusion
- significant medical conditions: irradiation in the maxillofacial area, uncontrolled diabetes or hypertension, systemic steroid or bisphosphonate treatment, pregnancy, or lactation, infectious diseases,
- age \<18 years, (3) smokers (\>5 cigarettes/day),
- high residual inflammation (FMBS \>25%),
- poor oral hygiene (FMPS \>25%), and
- defect-related factors: furcation involvement, endo-perio defects, horizontal defects, or multi-tooth defects .
Key Trial Info
Start Date :
September 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 25 2025
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT07183631
Start Date
September 1 2021
End Date
August 25 2025
Last Update
September 19 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Semmelweis University
Budapest, Hungary, 1088