Status:
RECRUITING
Platelet-Rich Plasma Versus Botulinum Toxin for Refractory Overactive Bladder: A Randomized Trial
Lead Sponsor:
Benha University
Conditions:
Overactive Bladder Syndrome
Urinary Urge Incontinence
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Overactive bladder is a common condition that causes sudden urges to urinate, frequent urination, night-time urination, and sometimes leakage of urine. Many people with overactive bladder improve with...
Eligibility Criteria
Inclusion
- Age 18 years or older
- History of urgency, frequency, nocturia, with or without urge urinary incontinence, lasting for at least 6 months
- Failure of standard medical treatment (antimuscarinics, beta-3 adrenergic agonists, or other appropriate therapy) for at least 6 months
- Willing and able to complete bladder diaries, questionnaires, and urodynamic testing
- Provides informed consent
Exclusion
- Pregnancy or lactation
- Previous intravesical biological therapy (e.g., platelet-rich plasma or botulinum toxin)
- Prior pelvic or bladder surgery that may affect bladder function
- Active urinary tract infection or sexually transmitted infection
- Vaginitis or chronic bacterial prostatitis
- Bladder or lower ureteral stones confirmed by imaging
- Bladder outlet obstruction on urodynamic study
- Bladder malignancy (mass on imaging or malignant cells on cytology)
- Use of indwelling urinary catheter
- Severe uncontrolled medical conditions (e.g., uncontrolled diabetes, advanced renal or hepatic impairment)
- Known hypersensitivity to botulinum toxin or contraindication to platelet-rich plasma preparation (e.g., coagulopathy, inability to discontinue anticoagulation safely)
Key Trial Info
Start Date :
April 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 15 2026
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT07184307
Start Date
April 15 2025
End Date
April 15 2026
Last Update
September 19 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Benha University Hospital, Faculty of Medicine, Department of Urology
Banhā, Qalyubia Governorate, Egypt, 13511