Status:
NOT_YET_RECRUITING
Effect of Sodium Glucose Co-transporter 2 Inhibitors on Left Atrial Remodeling in Diabetic Patients
Lead Sponsor:
Assiut University
Conditions:
SGLT 2 Inhibitors
Eligibility:
All Genders
40-75 years
Brief Summary
To evaluate and follow-up left atrial volume, diastolic function by 2D echocardiography and left atrial strain parameters using speckle-tracking echocardiography in patients with type 2 diabetes melli...
Detailed Description
Diabetes mellitus (DM) is a chronic metabolic disorder that significantly increases cardiovascular morbidity and mortality. Among the earliest manifestations of diabetic heart disease is subclinical c...
Eligibility Criteria
Inclusion
- Diagnosed T2DM on antidiabetic medication not including SGLT2 inhibitors.
- HbA1c ≤ 7%.
- Age 40-75 years.
- Sinus rhythm.
- Informed consent obtained
Exclusion
- History of atrial fibrillation or flutter.
- Patients treated with SGLT2 inhibitors.
- Severe mitral valve regurgitation or stenosis.
- Previous myocardial infarction.
- Previous percutaneous coronary intervention(PCI) or coronary artery bypass grafting (CABG).
- LV Ejection fraction \<50% .
- Severe renal impairment (eGFR \< 30 mL/min/1.73 m²)
- Uncontrolled hypertension (BP \> 160/100 mmHg)
- Inadequate echocardiographic windows or incomplete data
Key Trial Info
Start Date :
October 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT07186153
Start Date
October 1 2025
End Date
November 1 2026
Last Update
September 22 2025
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