Status:
NOT_YET_RECRUITING
Methylprednisolone vs Dexamethasone: Effects on Sugammadex Reversal, Pain, and Nausea in Adults
Lead Sponsor:
Konya City Hospital
Conditions:
Neuromuscular Block, Residual
Pain
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
This randomized controlled trial aims to compare the effects of intravenous methylprednisolone and dexamethasone on the reversal time of rocuronium by sugammadex in adult patients undergoing elective ...
Detailed Description
Neuromuscular blockade with rocuronium is routinely reversed with sugammadex. Corticosteroids such as methylprednisolone and dexamethasone are frequently used perioperatively for their anti-inflammato...
Eligibility Criteria
Inclusion
- Adult patients aged 18-65 years
- American Society of Anesthesiologists (ASA) physical status I-II
- Scheduled for elective septoplasty or rhinoplasty under general anesthesia
- Written informed consent obtained
Exclusion
- ASA physical status ≥ III
- Emergency surgery
- Known allergy or contraindication to rocuronium, sugammadex, or corticosteroids
- Chronic or recent (within 3 months) systemic corticosteroid therapy
- Concomitant use of drugs that may interact with sugammadex (e.g., toremifene, flucloxacillin, fusidic acid)
- Neuromuscular disorders (e.g., myasthenia gravis, muscular dystrophy)
- Significant hepatic, renal, respiratory, or cardiac dysfunction
- Anticipated difficult airway or history of difficult intubation
- Nasopharyngeal or oropharyngeal anomalies interfering with airway management
- Developmental or cognitive impairment interfering with informed consent or cooperation
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 30 2026
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT07187037
Start Date
October 1 2025
End Date
April 30 2026
Last Update
September 22 2025
Active Locations (1)
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1
Konya City Hospital
Karatay, Konya, Turkey (Türkiye), 42050