Status:
RECRUITING
Study of Axial and Cognitive Symptoms and Biomarkers of Neurodegeneration in Brain-first and Body-first PD
Lead Sponsor:
Azienda USL Reggio Emilia - IRCCS
Conditions:
Parkinson Disease
Parkinsonian Disorders
Eligibility:
All Genders
18+ years
Brief Summary
This observational study aims to systematically characterize a cohort of patients with early-stage Parkinson's disease (PD) attending the Movement Disorders Center of AUSL-IRCCS Reggio Emilia, Italy. ...
Detailed Description
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting up to 1% of individuals over the age of 60. While treatment remains symptomatic and n...
Eligibility Criteria
Inclusion
- Patients diagnosed with PD according to the MDS Clinical Diagnostic Criteria for Parkinson's Disease divided into brain-first and body-first phenotypes, based on the presence or absence of a REM sleep behavior disorder diagnosed using ambulatory polysomnography methods according to the criteria of the International Classification of Sleep Disorders (ICSD-3) criteria and on data from SPECT with DATSCAN and myocardial innervation scintigraphy \[123I-MIBG\].
- Free and informed consent expressed by the participant.
- At least 18 years of age.
Exclusion
- Inability to express free and informed consent.
- Patient with a doubtful diagnosis.
- Participant under 18 years of age.
Key Trial Info
Start Date :
September 4 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2031
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT07187843
Start Date
September 4 2024
End Date
May 1 2031
Last Update
September 23 2025
Active Locations (1)
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1
Azienda USL IRCCS di Reggio Emilia
Reggio Emilia, Italy