Status:
NOT_YET_RECRUITING
Rectal Misoprostol for Reducing Blood Loss in Elective Cesarean Section
Lead Sponsor:
Assiut University
Conditions:
Postpartum Hemorrhage
Eligibility:
FEMALE
18-45 years
Phase:
NA
Brief Summary
This randomized controlled trial aims to evaluate the efficacy of adding preoperative rectal misoprostol to standard oxytocin for reducing intraoperative and postoperative blood loss in women undergoi...
Detailed Description
Postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and mortality worldwide, with increased risk following cesarean section compared to vaginal delivery. Oxytocin is the standard uter...
Eligibility Criteria
Inclusion
- Women aged 18-45 years.
- Singleton pregnancy at ≥37 weeks of gestation.
- Elective cesarean section planned under spinal anesthesia.
- Hemodynamically stable prior to surgery.
- Provided written informed consent.
Exclusion
- Multiple pregnancy.
- Antepartum hemorrhage (e.g., placenta previa, abruption).
- Coagulopathy, thrombocytopenia, or anticoagulant therapy.
- Severe medical comorbidities (e.g., uncontrolled hypertension, cardiac disease, hepatic or renal impairment).
- Known allergy or contraindication to prostaglandins or oxytocin.
- Intrauterine fetal death or major fetal anomaly.
- Refusal to participate.
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
282 Patients enrolled
Trial Details
Trial ID
NCT07188207
Start Date
October 1 2025
End Date
December 31 2026
Last Update
September 23 2025
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