Status:
COMPLETED
Immunometabolism of Exercise
Lead Sponsor:
University of Houston
Conditions:
Cardiorespiratory Fitness and Acute Exercise
Eligibility:
All Genders
20-40 years
Phase:
NA
Brief Summary
This study aims to examine the effects of acute aerobic exercise and cardiorespiratory fitness on cellular metabolism of CD8+ T cells and regulatory T cells (Tregs) found in the peripheral blood of hu...
Eligibility Criteria
Inclusion
- Men and women, aged 20-40 years
- individuals presenting with average (40th-60th percentile) cardiorespiratory fitness (i.e., VO2max/VO2peak) for their age and sex will be included in acute exercise experiments; individuals with VO2max/VO2peak value \>20ml/kg/min will be included in cardiorespiratory fitness experiments
- individuals categorized as 'low risk' for a cardiovascular event/heart disease when screened by American College of Sports Medicine (ACSM) criteria
Exclusion
- adults under the age of 20 and over the age of 40
- Individuals with contraindications to exercise testing will be excluded
- Individuals with musculoskeletal impairments preventing them from exercising on a cycle ergometer
- Individuals with disease history known to impact the immune system and/or systemic metabolism will be excluded, including autoimmune diseases, HIV, Hepatitis, diabetes, cancer (completed treatment within \<6 months prior), hyper- or hypothyroidism
- Pregnancy
- Individuals using medications known to impact the cardiopulmonary and/or immune response to exercise with be excluded, including those using medication to control blood pressure (e.g., beta-blockers), daily steroidal and nonsteroidal anti-inflammatories (except daily aspirin), prescription allergy medication, ADHD medication (Ritalin or Adderall), thyroid medication (e.g., Levothyroxine), and chemotherapy (including treatments within the last 6 months).
- Individuals habitually using tobacco products within the last 6 months or with excessive alcohol intake (\>10 drinks/week)
Key Trial Info
Start Date :
March 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 3 2025
Estimated Enrollment :
102 Patients enrolled
Trial Details
Trial ID
NCT07188389
Start Date
March 1 2024
End Date
April 3 2025
Last Update
September 23 2025
Active Locations (1)
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1
University of Houston
Houston, Texas, United States, 77204