Status:
RECRUITING
CMT Gait, Mobility, Balance - AOFAS Grant
Lead Sponsor:
Bopha Chrea
Conditions:
Charcot Marie Tooth Disease (CMT)
Eligibility:
All Genders
25-55 years
Phase:
NA
Brief Summary
The overall objective of the proposed research is to begin to better understand the potential benefits and limitations of ankle -foot orthosis (AFO) use in the context of mobility and balance during g...
Detailed Description
Walking is an important daily activity that is compromised in individuals with neuromuscular conditions. Charcot-Marie-Tooth (CMT) disease is the most common form of inherited peripheral neuropathy, a...
Eligibility Criteria
Inclusion
- 1) Clinical diagnosis and genetic confirmation of CMT, 2) Between the ages of 12 and 75, 3) Able to walk at a slow to moderate pace without an AFO, 3) Able to read and write in English and provide written informed consent. 4) Individuals in the NonOP group must have an AFO prescribed for daily activities. Individuals in the OP group will also have had 5) surgical correction of CMT cavovarus foot deformity focused on muscle balancing and hindfoot correction.
Exclusion
- 1) Other causes or risk factors for peripheral neuropathy (for example diabetes, ETOH abuse), 2) Uncorrected visual impairment, 3) History of musculoskeletal injury requiring surgery 4) loss of plantar protective sensation 5) Pain \>4/10 while walking (or an increase in pain during testing of \>2/10), 6) Concern by the examiner that the individual will not complete the study. For the NonOP group 7) Previous surgical correction of CMT cavovarus foot deformity focused on muscle balancing and hindfoot correction
Key Trial Info
Start Date :
August 14 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2027
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT07188415
Start Date
August 14 2025
End Date
January 1 2027
Last Update
September 23 2025
Active Locations (1)
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1
University of Iowa Medical Campus - North Liberty (MCNL)
North Liberty, Iowa, United States, 52713