Status:
RECRUITING
IntHyx : Intubation Strategies for Patients With Acute Hypoxemic Respiratory Failure
Lead Sponsor:
University Hospital, Angers
Conditions:
Acute Hypoxemic Respiratory Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Acute hypoxemic respiratory failure requires endotracheal intubation and invasive mechanical ventilation in approximately 30-40% of cases, due to severe hypoxemia and/or clinical signs of acute respir...
Eligibility Criteria
Inclusion
- Adult patient
- Patient admitted to intensive care less than 24 hours ago
- Acute respiratory failure with hypoxemia defined by either:
- Oxygen therapy ≥ 10 L/min via high-concentration mask required for SpO2 ≥ 92%
- High-flow oxygen therapy with FiO2 ≥ 50% required for SpO2 ≥ 92%
- Informed consent of the patient or a trusted relative (when the patient is unable to give consent)
Exclusion
- Acute hypercapnic respiratory failure (defined by PaCO2 \> 45 mmHg)
- Cardiogenic pulmonary edema
- Exacerbation of chronic respiratory disease
- Respiratory failure requiring long-term oxygen therapy
- Neuromuscular disease
- Glasgow Coma Scale score ≤ 12
- Decision to intubate immediately
- Invasive mechanical ventilation within the previous 7 days
- Treatment limitation decisions for intubation
- Person deprived of liberty by judicial or administrative decision : Person undergoing compulsory psychiatric care, person subject to legal protection measures, Pregnant, breastfeeding, or parturient patient
Key Trial Info
Start Date :
December 13 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2027
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT07189078
Start Date
December 13 2025
End Date
March 1 2027
Last Update
December 29 2025
Active Locations (9)
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1
Angers University Hospital, ICU
Angers, France
2
Le Mans Hospital, ICU
Le Mans, France
3
Nantes University Hospital, ICU
Nantes, France
4
Orléans University hospital, ICU
Orléans, France