Status:
NOT_YET_RECRUITING
Study-group on Palliative ERCP And RFA-ablation in Metastatic and Inoperable Pancreatic Tumors
Lead Sponsor:
Roberto Valente
Conditions:
Pancreatic Cancer Metastatic to Liver
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive cancer and may become the second leading cause of cancer death by 2030. About half of the patients are diagnosed late, when the cancer has ...
Detailed Description
Pancreatic cancer is rapidly becoming a medical emergency. Its prognosis continues to worsen and it is projected to become the second leading cause of cancer-related deaths by 2030. At diagnosis, app...
Eligibility Criteria
Inclusion
- Individuals with newly diagnosed pancreatic cancer in the head of the pancreas causing compression on the bile duct.
- Metastatic stage to the liver
- Histologically or cytologically confirmed mPDAC.
- Cancer burden limited to maximum 5 metastases in the liver, each of them maximum 1 cm in the larger diameter.
- Patients must be under palliative chemotherapy treatment.
- Cancer should be radiologically measurable (in an area not previously irradiated).
- WHO performance status 0-2.
- Age 18-85 years.
Exclusion
- Intellectual disability, unwillingness or language difficulties
- which hinders the ability to give informed consent.
- Ongoing extensive immunosuppression and/or severe leuko- or
- thrombocytopenia.
- Ongoing acute cholangitis.
- Ongoing sepsis.
- Acute kidney failure.
- Uncompensated heart failure or unstable coronary insufficiency
- (symptomatic/uncompensated).
- Pregnancy or breastfeeding.
- Any metastases outside the liver.
- Cardiac pacemakers/cardioverter defibrillators.
- Severe coagulopathy.
Key Trial Info
Start Date :
September 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2027
Estimated Enrollment :
178 Patients enrolled
Trial Details
Trial ID
NCT07191418
Start Date
September 1 2025
End Date
September 1 2027
Last Update
September 24 2025
Active Locations (1)
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1
Department of Surgery, Umeå University Hospital
Umeå, Sweden, 90185