Status:
COMPLETED
Pancake Oral Immunotherapy For Egg Allergy In Inducing Tolerance
Lead Sponsor:
KK Women's and Children's Hospital
Conditions:
Egg Allergy
Eligibility:
All Genders
2-15 years
Phase:
NA
Brief Summary
Oral immunotherapy (OIT) using raw/ cooked egg has good desensitisation outcomes but is associated with frequent and sometimes severe adverse events (anaphylaxis is not uncommon). OIT using baked egg ...
Eligibility Criteria
Inclusion
- Allergic to 4.443g egg protein or less, at baseline egg open food challenge OR Convincing clinical reaction to egg within past 6 months (or failed a clinical egg food challenge in last 6 months) AND evidence of current sensitization (positive SPT or egg-specific IgE performed within the last 3 months)
Exclusion
- Subjects meeting any of the exclusion criteria at baseline will be excluded from participation.
- Required previous admission to an intensive care unit for management of an allergic reaction.
- Children with a past history of egg allergy currently consuming egg-containing products other than extensively-heated egg in baked foods (e.g. biscuits, cakes).
- Developed severe anaphylaxis to egg or egg-containing products requiring more than 2 adrenaline auto-injectors or intravenous adrenaline infusion.
- Poorly controlled asthma within the previous 3 months (as defined by clinician judgement with reference to the ICON guidelines).
- Moderate-severe eczema despite appropriate use of emollients (eczema is not otherwise an exclusion criteria).
- Clinically significant chronic illness (other than asthma, rhinitis or eczema).
- History of symptoms of eosinophilic oesophagitis, irrespective of cause.
- Undergoing specific immunotherapy to another allergen and within the first year of treatment.
- Receiving anti-IgE therapy, oral immunosuppressants, beta-blocker or ACE inhibitor.
- Pregnancy.
- Unwilling or unable to fulfil study requirements.
Key Trial Info
Start Date :
April 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 16 2025
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT07192510
Start Date
April 1 2021
End Date
April 16 2025
Last Update
September 25 2025
Active Locations (1)
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1
KK Women's and Children's Hospital
Singapore, Singapore