Status:
COMPLETED
Effect of Fruit Elicitation With Melatonin on Human Health
Lead Sponsor:
Universidad Miguel Hernandez de Elche
Collaborating Sponsors:
National Research Council, Spain
Conditions:
Healthy
Dietary Bioavailability
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The goal of this clinical trial is to learn if treating fruits with melatonin helps the body absorb and use healthy plant compounds. It will also learn how much melatonin from the fruits is taken up b...
Detailed Description
This clinical trial will investigate whether melatonin treatments in fruits can improve the bioavailability of bioactive compounds in humans. Melatonin is a natural molecule with antioxidant and prote...
Eligibility Criteria
Inclusion
- Healthy adults aged 18-65 years
- Body mass index (BMI) between 18.5 and 24.9 kg/m²
- Non-smokers
- No chronic diseases (such as diabetes, cardiovascular disease, or cancer)
- Not taking regular medication
- Willing to follow a diet low in phenolic compounds and melatonin during the study periods
- Able and willing to provide urine samples according to study instructions
Exclusion
- Presence of chronic diseases or metabolic disorders
- Use of medications that could affect metabolism or absorption of compounds
- Smoking or use of nicotine products
- Allergies or intolerance to citrus fruits or cherries
- Pregnancy or breastfeeding
- Inability or unwillingness to comply with study procedures or dietary restrictions
Key Trial Info
Start Date :
March 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2025
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT07192835
Start Date
March 1 2025
End Date
August 1 2025
Last Update
September 25 2025
Active Locations (1)
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1
University Miguel Hernandez
Orihuela, Alicante/Alacant, Spain, 03312