Status:
NOT_YET_RECRUITING
Glymphatic Function TMS Study
Lead Sponsor:
University of Arizona
Conditions:
Mild Cognitive Impairment
Eligibility:
All Genders
50-85 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to use transcranial magnetic stimulation (TMS) in older adults to impact the glymphatic system. The glymphatic system is a brain-wide clearance pathway that plays a crucia...
Eligibility Criteria
Inclusion
- Individuals with mild cognitive impairment (MCI Group)
- Age 18-85 years
- MCI subjective criteria: self- or informant-reported cognitive complaint
- Objective cognitive impairment supported by one of the following measures of general cognitive function: (a) classified as MCI via the NACC-UDS 3.0 neuropsychological battery using the typical neuropsychological criteria for MCI diagnosis (1 score on any test at least1.5 SD below the mean); or (b) classified as MCI via the NACC-UDS 3.0 neuropsychological battery using the Jak/Bondi neuropsychological criteria for MCI diagnosis(2 scores at least 1 SD below the mean in one domain, or 3 scores at least 1SD below the mean across domains)
- Right-handed
- English speaking
- Able to attend daily intervention and outcome measurements for \~15 days over a 6 month period.
- Not enrolled in another interventional study within 6 months prior to beginning this study
Exclusion
- Contraindications to transcranial magnetic stimulation (TMS) or magnetic resonance imaging (MRI)
- Reported sudden or steep decline of cognitive performance
- Telephone Interview for cognitive impairment (TICS) score
- Other neurological disorders (e.g., stroke, head injuries, or multiple sclerosis)
- Psychiatric disorder (except stable late-life depression due to its high prevalence in MCI individuals)
- Current cancer treatment or other comorbid/unstable medical conditions that might independently affect cognitive function
Key Trial Info
Start Date :
January 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2026
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT07192913
Start Date
January 1 2026
End Date
July 1 2026
Last Update
December 17 2025
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