Status:
ACTIVE_NOT_RECRUITING
Sarcopenia and CRP-TyG Index (CTI) as Predictors of Immunotherapy Response in Metastatic Non-Small Cell Lung Cancer
Lead Sponsor:
Ankara Etlik City Hospital
Conditions:
Metastatic Non-small Cell Lung Cancer
Neoplasm
Eligibility:
All Genders
18+ years
Brief Summary
This study investigates the impact of sarcopenia and the CRP-TyG Index (CTI) on immunotherapy outcomes in patients with metastatic non-small cell lung cancer (NSCLC). Medical records of 115 adult pati...
Detailed Description
Metastatic non-small cell lung cancer (mNSCLC) is among the leading causes of cancer-related mortality worldwide. Immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1 have improved survival outcom...
Eligibility Criteria
Inclusion
- Age ≥18 years.
- Histologically confirmed diagnosis of metastatic non-small cell lung cancer (mNSCLC).
- Received at least one cycle of immune checkpoint inhibitor (PD-1 or PD-L1 inhibitor) as part of routine clinical care.
- Availability of baseline CT imaging (within 4 weeks before treatment initiation) and follow-up CT imaging at approximately 3 months.
- Availability of baseline laboratory data including C-reactive protein (CRP), triglycerides, and fasting glucose.
- Adequate clinical records for evaluation of treatment response and survival outcomes.
Exclusion
- Age \<18 years.
- Patients without immunotherapy treatment.
- Incomplete or missing CT imaging or laboratory data required for sarcopenia or CTI assessment.
- Patients lost to follow-up before first radiological evaluation.
- Prior malignancy within 5 years (except adequately treated basal cell carcinoma of the skin or carcinoma in situ of the cervix).
Key Trial Info
Start Date :
November 15 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 15 2025
Estimated Enrollment :
115 Patients enrolled
Trial Details
Trial ID
NCT07192926
Start Date
November 15 2022
End Date
December 15 2025
Last Update
October 2 2025
Active Locations (2)
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1
Etlik City Hospital Medical Oncology Department
Ankara, Yenimahalle, Turkey (Türkiye), 06270
2
Etlik City Hospital Radiology Department
Ankara, Yenimahalle, Turkey (Türkiye), 06270