Status:
RECRUITING
ECG-less Coronary Computed Tomography Angiography in the Management of Patients Presenting With High-troponin Chest Pain
Lead Sponsor:
Universitair Ziekenhuis Brussel
Conditions:
Chest Pain
Acute Coronary Syndromes (ACS)
Eligibility:
All Genders
30+ years
Phase:
NA
Brief Summary
Chest pain represents a common reason for consultation to emergency room. This symptom can be explained by a broad spectrum of conditions, from benign musculoskeletal or esophageal pain to life-threat...
Detailed Description
1. Study Rationale The aim is to investigate the potential role of CCTA in patients presenting to the emergency room with thoracic pain and elevated troponins. Using a single contrast bolus and a lowe...
Eligibility Criteria
Inclusion
- Age ≥ 30 years old
- Admission at the ER with acute chest pain and at least one of the follow-ing:
- ECG abnormality;
- positive rule-in criteria according to the ESC guidelines (hs-cTnT ≥ 52 in at least one assay or 1h ∆ ≥ 5);
- troponine value in the "observe pathway" (hs-cTnT ≥ 12 in at least one assay or 1h ∆ ≥ 3) AND a high clinical suspicion of MI.
Exclusion
- Indication for urgent ICA (ST-elevation, hemodynamic or electric instabil-ity, refractory chest pain, mechanical complications)
- eGFR \< 30 ml/min
- Previous coronary stenting
- Previous CABG
- Recent ACS within 6 months
- Known severely reduced ejection fraction (EF \< 30%)
- Contrast allergy
- Inability to provide informed consent
- Limited life expectancy \< 2 years due to non-cardiac conditions
- Pregnant and breast-feeding women
- Known congenital heart disease
- Atrial fibrillation
Key Trial Info
Start Date :
September 10 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2028
Estimated Enrollment :
230 Patients enrolled
Trial Details
Trial ID
NCT07192965
Start Date
September 10 2025
End Date
March 1 2028
Last Update
September 25 2025
Active Locations (1)
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1
Universitair Ziekenhuis Brussel
Jette, Belgium, 1090